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ba0001pp182 | Cell biology: osteoblasts and bone formation | ECTS2013

Evaluation of bone formation capacities of human adipose-derived stromal cells cultured in platelet growth factor-enriched plasma medium.

Guilloton Fabien , Rabani Vahideh , Brennan Meadhbh , Bassi Giulio , Krampera Mauro , Layrolle Pierre , Sensebe Luc , Deschaseaux Frederic

Human adipose-derived stromal cells (ASCs) exhibit strong plasticity and proliferation potentials. In addition, ASCs are easy to harvest and are found at high frequency in adipose tissue samples. This gives us opportunities for their use in bone regeneration therapy. We thus evaluated the bone formation potential of ASCs in vitro and in vivo.ASCs were isolated from subcutaneous adipose tissue (following Local Ethical Guideline and after...

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ba0003pp375 | Other diseases of bone and mineral metabolism | ECTS2014

Osteoprotegerin and bone-like vascular calcification are predictive markers of vulnerable carotid plaques

Heymann Marie Francoise , Davaine Jean Michel , Laperine Olivier , Merlini Thierry , Guyomarch Beatrice , Chatelais Mathias , Guilbaud Florian , Brennan Meadhbh Aine , Heymann Dominique , Goueffic Yann

Vascular calcification has a marked impact on arterial heterogeneity and plaque stability. Based on a cohort of 116 patients (carotid and femoral endarterectomies), the aim of the present study was to determine the influence of the bone-like vascular calcification and of osteoprotegerin (OPG) on plaque stability.Seventy-three carotid and 43 femoral plaques along with plasma were harvested and analyzed in a single center study. The presence of osteoid met...

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Bone Abstracts

Evaluation of bone formation capacities of human adipose-derived stromal cells cultured in platelet growth factor-enriched plasma medium.

Osteoprotegerin and bone-like vascular calcification are predictive markers of vulnerable carotid plaques

BiosciAbstracts